Here at HubCityLabs, we have a great, dustless way to cut and depanelize PCBs. We use a Grizzly Mini Shear. The Grizzly Mini Shear produces are clean, professional edge for almost any DIY sized projects.
We frequently order panelized PCBs from SeeedStudio, and depanelizing them with this tool is a breeze. At 150$, it’s decently priced for most DIYers or Hackerspaces.
As a bonus, this shear will let you cut sheet metal, and bend them to make metal enclosures.